VITAMIN E AND CANCER

About Vitamin E

The following information on general explanation of vitamin E, please see: (www.toosogie-health)

The Introductory Notes About Vitamin E Potential For Cancer

The study found no beneficial effect of vitamin E supplements on lung cancer incidence. It found lower rates of prostate and colorectal cancer among those who received vitamin E, but higher rates of bladder, stomach, and other types of cancer.

Studies and Statements to Future Potential of Vitamin E For Cancer

Vitamin E and cancer
Kline K, Lawson KA, Yu W, Sanders BG.
Division of Nutrition, University of Texas at Austin, Texas 78712, USA.

This chapter will review basic information about natural and synthetic vitamin E compounds as well as vitamin E analogues, summarize the current status of human intervention trials, review data from preclinical cell culture and animal model studies of vitamin E compounds and novel vitamin E-based analogues in regards to future potential for cancer treatment, and summarize some of the insights that have been gained into the anticancer mechanisms of action of vitamin E-based compounds which are providing interesting insights into their potent proapoptotic effects, which include restoration of apoptotic signaling pathways and blockage of prosurvival signaling events. PMID: 17628185 [PubMed - indexed for MEDLINE]; Vitam Horm. 2007;76:435-61. ….. More


Vitamin E and cancer prevention: recent advances and future potentials
K. N. Prasad and J. Edwards-Prasad
Department of Radiology, School of Medicine, University of Colorado Health Sciences Center, Denver 80262.

Human epidemiologic studies utilizing retrospective and prospective case-control experimental designs are not suitable for evaluating the role of vitamin E in cancer prevention due to several inherent problems associated with these methodologies. Intervention trials utilizing vitamin E with appropriate biological and statistical rationales are most suitable for testing the role of vitamin E in cancer prevention in humans. Some human trials utilizing vitamin E alone or in combination with other nutrients are in progress. [Jounal Article] …. More


Supplemental and Dietary Vitamin E Intakes and Risk of Prostate Cancer in a Large Prospective Study
Margaret E. Wright, Stephanie J. Weinstein, Karla A. Lawson, Demetrius Albanes, Amy F. Subar, L. Beth Dixon, Traci Mouw, Arthur Schatzkin and Michael F. Leitzmann

In summary, we found no overall association between vitamin E supplement use and prostate cancer. However, higher intake of γ-tocopherol was associated with a significant reduction in the risk of advanced prostate cancer, providing support for continued research efforts directed towards this vitamin E isoform. . (Cancer Epidemiol Biomarkers Prev 2007;16(6):1128–35) … More


The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group
[No authors listed]

We found no reduction in the incidence of lung cancer among male smokers after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene. In fact, this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects. PMID: 8127329 [PubMed - indexed for MEDLINE];Abstract N Engl J Med. 1994 Apr 14;330(15):1029-35. … More


Vitamin E and cancer prevention
P Knekt, A Aromaa, J Maatela, RK Aaran, T Nikkari, M Hakama, T Hakulinen, R Peto and L Teppo
Social Insurance Institution, Helsinki, Finland.

The strength of the association between serum alpha-tocopherol level and cancer risk varied for different cancer sites and was strongest for some gastrointestinal cancers and for the combined group of cancers unrelated to smoking. The association was strongest among nonsmoking men and among women with low levels of serum selenium. The findings agree with the hypothesis that dietary vitamin E in some circumstances protects against cancer. [REVIEW ARTICLES] …. More


Prostate Cancer Throws Vitamin E Another Strike
By ADAM VOILAND

Some 35,000 men who participated in a major prostate cancer prevention trial are in the process of getting this disheartening—yet not entirely surprising—letter in the mail from the National Cancer Institute. The message: Vitamin E and selenium, long buzzed about for their supposed prostate cancer-fighting properties, have flopped. Flopped hard. [Article] … More


A prospective study on supplemental vitamin e intake and risk of colon cancer in women and men
Wu K, Willett WC, Chan JM, Fuchs CS, Colditz GA, Rimm EB, Giovannucci EL.
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. kana.wu@channing.harvard.edu
Our findings do not provide consistent support for an inverse association between supplemental vitamin E and colon cancer risk. Considering the paucity of epidemiological data on this association, further studies of vitamin E and colon cancer are warranted. (abstact; PMID: 12433706 [PubMed - indexed for MEDLINE]
Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1298-304.) …. More


Vitamin C and vitamin E supplement use and bladder cancer mortality in a large cohort of US men and women
Jacobs EJ, Henion AK, Briggs PJ, Connell CJ, McCullough ML, Jonas CR, Rodriguez C, Calle EE, Thun MJ.
Department of Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30329-4251, USA. eric.jacobs@cancer.org

Some epidemiologic studies suggest that use of vitamin C or vitamin E supplements, both potent antioxidants, may reduce the risk of bladder cancer. ……. Results support the hypothesis that long-duration vitamin E supplement use may reduce the risk of bladder cancer mortality. PMID: 12446256 [PubMed - indexed for MEDLINE]; Abstract, Am J Epidemiol. 2002 Dec 1;156(11):1002-10. …. More


Selenium and Vitamin E Cancer Prevention Trial (SELECT)

However, the Selenium and Vitamin E Cancer Prevention Trial, ("SELECT"), run from 2004 to 2008, found that vitamin E, whether taken alone or in combination with selenium, did not prevent prostate cancer. [Article] …. More


A comparison of tocopherol and tocotrienol for the chemoprevention of chemically induced rat mammary tumors
Gould MN, Haag JD, Kennan WS, Tanner MA, Elson CE.
Department of Human Oncology, University of Wisconsin-Madison 53792.

Two forms of vitamin E, tocopherol and tocotrienol, were tested for chemopreventive activity in two chemically induced rat mammary-tumor models. When mammary tumors were induced by 7,12-dimethylbenz(a)anthracene (DMBA, 50 mg/kg), only the tocotrienol group had a statistically significant increase in tumor latency. There was no effect of either compound on tumor multiplicity. When tumors were induced by N-nitrosomethylurea (NMU, 30 mg/kg), neither analogue of vitamin E modified latency, whereas tocotrienol increased tumor multiplicity. In summary, neither vitamin analog had a major impact on mammary-tumor development after tumor induction with either DMBA or NMU.
PMID: 1845366 [PubMed - indexed for MEDLINE]; Abstract, Am J Clin Nutr. 1991 Apr;53(4 Suppl):1068S-1070S. … More